SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age
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SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age
L1 retrotransposons are an abundant class of transposable elements that pose a threat to genome stability and may have a role in age-related pathologies such as cancer. Recent evidence indicates that L1s become more active in somatic tissues during the course of ageing; however the mechanisms underlying this phenomenon remain unknown. Here we report that the longevity regulating protein, SIRT6,...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2014
ISSN: 2041-1723
DOI: 10.1038/ncomms6011